The Radford family have had to wave goodbye to one of their daughter's who moved out to live with her boyfriend.
Before she left the family home, Chloe, 25, was the eldest of the 19 children still living in the 10-bed house in Lancashire.
Chris, 31, and Sophie, 27, had already left parents Sue and Noel to start their own families.
Now Chloe has announced she has left the family home to live with her boyfriend Jake Wallace.
She posted the news on Instagram, writing: "Few drinks to celebrate living together."
The make-up artist tagged her partner Jake, adding: "Might need something a big stronger than a pint."
The news comes as the Britain's biggest family revealed they are about to get bigger.
It was announced Chris is expecting his third baby with his wife who is due to give birth in September.
He shared a photo of the baby scan over the weekend, writing: "So that's baby number 3 cooking nicely another little boy."
Sue and Noel also have grandkids Daisy, eight, Ayprill, six, and Leo, five, to daughter Sophie, 27, and her husband, Joe.
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Also the parents welcomed baby Ophelia last September after 19-year-old Millie gave birth.
Speaking about the latest addition of the Radford family, the couple explained how excited they were about the news.
Posting online, Sue wrote: "Another beautiful grandson on the way."
And after giving birth to Heidie in lockdown last year, the mum-of-22 revealed she won't be having anymore children.
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It is believed the couple support their massive brood using money from their pie shop.
On their recent Channel 5 programme 22 Kids & Counting, Sue revealed they had spent a whopping £1million on raising their kids.
She also explained that she's been pregnant for 16 and a half years of her life.
Noel revealed: "It's a huge responsibility having 22 kids. I try not to let it get to me."
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