Saphier is a breast radiologist and director of breast imaging at Memorial Sloan Kettering Cancer Center-Monmouth. She also authored a book critiquing the U.S. response to the Covid-19 pandemic and previously served as a Fox News contributor.

Means’ nomination stalled amid criticism over her controversial stances on vaccines and other health issues. Her confirmation hearing took place on February 25, 2026, but Senator Bill Cassidy’s opposition was notable.

Trump criticized Cassidy for blocking Means’ nomination, stating, “Nicole is a STAR physician who has spent her career guiding women facing breast cancer through their diagnosis and treatment.” He praised Saphier’s advocacy for early cancer detection and prevention.

Trump also highlighted her skills in health communication, saying she is an “INCREDIBLE COMMUNICATOR” who simplifies complex health issues for Americans. Saphier hosts a health and wellness podcast called ‘Wellness Unmasked,’ further emphasizing her focus on public health education.

Meanwhile, Means is pursuing a career in functional medicine, which led to her medical license becoming inactive. She is the sister of Calley Means, a senior White House adviser.

Despite the setback for Means, Trump expressed confidence in Saphier’s ability to address important health issues facing the country. He noted that she will play a crucial role in the ongoing MAHA Movement aimed at improving health outcomes.

The shift in nominations reflects a broader strategy by Trump to align his administration with candidates who can effectively communicate public health messages during challenging times.

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